Degradation of superparamagnetic iron oxide nanoparticle-induced ferritin by lysosomal cathepsins and related immune response
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چکیده
منابع مشابه
Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.
Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to p...
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The aim of this study is to obtain polysaccharide (Glucose, Fructose and Sucrose) stabilized superparamagnetic iron oxide nanoparticles (SPIONs) by Co-Precipitation method. As prepared iron oxide nanoparticles have been characterized by X-ray Diffraction (XRD), Fourier Transform infrared (FTIR) spectroscopy, UV–Vis NIR spectroscopy, High Resolution Transmission Electron Microscope (HRTEM) and V...
متن کاملSynthesis and characterization of superparamagnetic Iron Oxide nanoparticles (SPIONs) stabilized by Glucose, Fructose and Sucrose
The aim of this study is to obtain polysaccharide (Glucose, Fructose and Sucrose) stabilized superparamagnetic iron oxide nanoparticles (SPIONs) by Co-Precipitation method. As prepared iron oxide nanoparticles have been characterized by X-ray Diffraction (XRD), Fourier Transform infrared (FTIR) spectroscopy, UV–Vis NIR spectroscopy, High Resolution Transmission Electron Microscope (HRTEM) and V...
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A cellular feature of Parkinson's disease is cytosolic accumulation and amyloid formation of α-synuclein (α-syn), implicating a misregulation or impairment of protein degradation pathways involving the proteasome and lysosome. Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease for α-syn clearance; however, the protease alone only generates amyloidog...
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ژورنال
عنوان ژورنال: Nanomedicine
سال: 2012
ISSN: 1743-5889,1748-6963
DOI: 10.2217/nnm.11.148